10 Memorable General Hospital Celebrity Cameos

The show scored a 1981 visit from Milton Berle, who played Tiffany Hill's (Sharon Wyatt) modeling agent, Mickey Miller.

In the mother of all high-wattage guest star turns, Elizabeth Taylor, an avowed Luke (Anthony Geary) and Laura fan, created the role of Helena Cassadine during a brief stint in 1981. As part of her memorable appearance, Helena placed a curse on Luke and Laura on their wedding day. Geary became close with Taylor, and upon her passing, said in a statement, "I was fortunate enough to call her my friend and every moment I spent in her company was unforgettable. I loved her very much. The world is a little darker, a little colder, a little less beautiful without her."

Rat Pack legend Sammy Davis Jr. was a fan of ABC soaps, and in 1982, he did a stint on GH as recovering alcoholic Eddie Phillips, who came to town to patch things up with his son Bryan (Todd Davis), from whom he was estranged. Also pictured: Bianca Ferguson as Claudia Johnston.

When John Stamos returned to GH, where he began his career as Blackie Parrish (1982-84) in 1992, it was to play himself in scenes with his real-life buddy Kin Shriner (Scotty). In June 2024, he shared a clip of his cameo on his Instagram, writing, "I did a guest spot on @generalhospitalabc years ago as myself and of course, got to work with one of my all-time favorite actors and good friend @kinshriner We were just watching this scene together, laughing our asses off so we decided to post it. I’ve said it before, I’ll say it again -without General Hospital I’d probably still be flipping burgers at my dad‘s restaurant. I’m so grateful to the cast, crew and my good friends that were great mentors and great teachers. God bless General Hospital!"

In 1994, Roseanne Barr and her then-husband, Tom Arnold, popped up as Jennifer Smith, Luke's former fiancée, and Billy "Baggs" Boggs, respectively, in scenes with Anthony Geary and Genie Francis (Laura) set in Atlantic City.

Titanic’s Gloria Stuart (l., with Tamara Braun as Carly Corinthos and Rick Hearst as Ric Lansing) appeared in the role of mob widow Catherine in 2002.

American Idol judge Randy Jackson offered his expertise to Lesli Kay’s Lois Cerullo in 2004.

When Nikolas Cassadine (then-Tyler Christopher) was shot in 2013, he was tended to by a doctor named Kelly, in a cameo by Katie Couric.

Dancing With The Stars pro Maksim Chmerkovskiy appeared in 2013 as Anton, who volunteered to help choreograph the Nurses' Ball, in 2013. Lynn Herring (Lucy), who shared scenes with him, told Digest in 2023, "Maksim was so charming and what was fun was that doing our show was one of his first acting experiences. In one of the scenes, he was on a ladder and he missed a cue and I helped him out and he thanked me and so we had this kind of mutual respect going. But when we had to dance, he really had to twirl me around, and he said to me, ‘Please, I know what I’m doing. Let me lead.’ I almost died from embarrassment because I’m so used to, you know, just twirling around and doing silly things that I think I was forcing him around! I could barely talk, but I said, ‘Sorry!’ and we kept dancing."

Grey's Anatomy fave Chandra Wilson has made multiple appearances on the show, including playing one of Dr. Kevin Collins’s patients in 2014 scenes with Roger Howarth’s Franco Baldwin.